Natali was born in L’Aquila in 1958. He graduated in International Political Sciences and later Philosophy, starting his diplomatic career in 1986. In 1989, he was in Quito (Ecuador) as First Secretary of Commerce and Vicar of the Mission Leader. In 1993, he was in Helsinki (Finland), as Advisor and Vicar of the Mission Leader: specifically, he followed the Finnish process of adhesion in the European Union. At the end of 1996, he returned to the Ministry for the Press and Information Services.
In 2001, he was in Washington: as First Advisor for press and information, he was responsible for the relationships with the media during the delicate years following the terrorist attacks in New York and Washington, in conjunction with the wars in Afghanistan and Iraq. He was also responsible for the promotion of the Italian culture in the United States. On September 2005, he was appointed General Consul in Barcelona. He came back to the Ministry in 2009, as Head of the Private Secretariat of State Undersecretary Vincenzo Scotti. Plenipotential Minister in January 2010, he maintained his role as Head of the Secretariat of the deputy ministers Staffan de Mistura and, later, Lapo Pistelli.
In 2013, Roberto Natali became the Italian Ambassador to the Kingdom of Morocco. In 2014 he was appointed Italian Ambassador to the Islamic Republic of Mauritania.